Description

Dioscorea is a common vegetable that is widely used in traditional Chinese medicine and contains a variety of bioactive ingredients, such as saponins, diosgenin, and flavonoids. Saponins have been shown to have antithrombotic activity (Li et al., 2010; Zhang et al., 2013). In one study, total steroid saponins, derived from Dioscorea zingiberensis roots, blocked platelet aggregation, leading to prolonged partial thromboplastin activation time (APTT), thrombin time (TT), and prothrombin time (PT) in rats and prolonged bleeding and coagulation time in mice, suggesting the ability to reduce CVD (Li et al., 2010). In another study, researchers evaluated the antithrombotic effects of four types of diosgenyl saponins (Zhang et al., 2013).

The observations showed that diosgenyl β-D-galactopyranosyl-(1 → 4)-D-glycopyranoside, a new saponin disaccharide, showed excellent efficacy in prolonging bleeding time. In addition, it could significantly and dose-dependently inhibit platelet aggregation, prolong APTT, and inhibit factor VIII activities in rats. Overall, it could be concluded that diosynyl